Prediction of Successful Sperm Retrieval in Patients with Nonobstructive Azoospermia
Prediction of Successful Sperm Retrieval in Patients with Nonobstructive Azoospermia
Blog Article
Normal 0 false false false EN-US X-NONE vlone stop snitching shirt AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.
0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Introduction: Our aim was to evaluate the predictive values of factors that indicate successful sperm retrieval in men with nonobstructive azoospermia.Materials and Methods: We evaluated 85 infertile men with nonobstructive azoospermia who underwent multiple bilateral testicular biopsies.Factors including age, infertility period, surgical history, testicular volume, testicular consistency, serum follicle-stimulating hormone (FSH), serum inhibin B, serum luteinizing hormone, and serum total testosterone were assessed in relation to sperm retrieval results.
Results: Spermatozoa were retrieved in 18 biopsies (21.2%).Follicle-stimulating hormone, serum inhibin B, and testicular volume were associated with the results of sperm retrieval.Men with a higher testicular volume, a higher serum inhibin B, and a lower FSH had successful sperm retrieval.
The cutoff points were determined as 9.5 mL for testicular volume, 9.9 IU/L for serum FSH, the lazy susan ramen and 39.8 pg/mL for serum inhibin B.
These 3 factors had strong correlations with each other.The sensitivities and specificities were 88.9% and 94% for testicular volume, 97% and 83.3% for FSH, and 72.
2% and 95.5% for serum inhibin B, respectively.The positive predictive value for a combination of serum FSH and inhibin B was 100%.Conclusion: Serum FSH and serum inhibin B are useful markers for evaluation of the presence of sperm in patients with nonobstructive azoospermia.
Inhibin B has a high specificity when combined with serum FSH and their measurements can be helpful in all patients with nonobstructive azoospermia before decision making for sperm retrieval.